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Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19

Neutrophilia occurs in patients infected with SARS-CoV-2 (COVID-19) and is predictive of poor outcomes. Here, we link heterogenous neutrophil populations…

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ASMase is Essential for the Immune Response to Partial-Tumor Radiation Exposure

Background/aims: Tumor response to radiation is thought to depend on the direct killing of tumor cells. Our laboratory has called…

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Imaging Giardia intestinalis cellular organisation using expansion microscopy reveals atypical centrin localisation

doi: 10.1016/j.exppara.2024.108831. Online ahead of print. Affiliations Expand Affiliations 1 Institute of Immunology and Microbiology, First Faculty of Medicine, Charles…

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Comparison of mouse models of heart failure with reduced ejection fraction

Aims: Heart failure with reduced ejection fraction (HFrEF) is a leading cause of death worldwide; thus, therapeutic improvements are needed.…

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Esophageal chemical burns as a risk factor for esophageal malignancies: in-silico analyses – experimental research

Introduction: Esophageal chemical burns often occur through accidental or intentional oral consumption of chemical agents and lead to severe complications…

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Integrating network analysis with differential expression to uncover therapeutic and prognostic biomarkers in esophageal squamous cell carcinoma

Introduction: Esophageal squamous cell carcinoma (ESCC) accounts for over 90% of all esophageal tumors. However, the molecular mechanism underlying ESCC…

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Immunogenicity and safety of different combinations involving a third booster dose of SARS-CoV-2 inactivated vaccine, inactivated quadrivalent influenza vaccine, and 23-valent pneumococcal polysaccharide vaccine in adults aged ≥60 years: a phase 4, randomized, open-label study

Background: Concomitant administration of COVID-19, influenza, and pneumococcal vaccines could reduce the burden on healthcare systems. However, the immunogenicity and…

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Elucidating the role of tumor-associated ALOX5+ mast cells with transformative function in cervical cancer progression via single-cell RNA sequencing

Background: Cervical cancer (CC) is the fourth most common malignancy among women globally and serves as the main cause of…

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Effects of Corticosteroid Treatment on Olfactory Dysfunction in LATY136F Knock-In Mice

Objective: Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory condition affecting multiple organs, including the pancreas, salivary glands, lungs, kidneys,…

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Effects of Corticosteroid Treatment on Olfactory Dysfunction in LATY136F Knock-In Mice

Objective: Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory condition affecting multiple organs, including the pancreas, salivary glands, lungs, kidneys,…

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